ACCase 6 is the essential acetyl-CoA carboxylase involved in fatty acid and mycolic acid biosynthesis in mycobacteria
نویسندگان
چکیده
منابع مشابه
Mode of Action of Herbicides Affecting Acetyl-CoA Carboxylase and Fatty Acid Biosynthesis
The mode o f action o f cyclohexane-l,3-dione-type (cycloxydim, clethodim , sethoxydim, tralkoxydim ) and aryloxyphenoxypropanoate-type herbicides (diclofop, fenoxaprop, haloxyfop, fluazifop) is sum m arized in this review. Both herbicide classes, though structurally com pletely different, specifically block the same target enzyme i.e. the plastid acetyl-CoA carboxy lase (ACC) (EC 6.4.1.2). ...
متن کاملFatty-Acid Biosynthesis and Acetyl-CoA Carboxylase as a Target of Diclofop, Fenoxaprop and other Aryloxy-phenoxy-propionic Acid Herbicides
The effect of the herbicides and aryloxy-phenoxy-propionic acid derivatives diclofop, fenoxaprop, fluazifop and haloxyfop and their ethyl, methyl or butyl esters on the de novo fatty-acid biosynthesis of isolated chloroplasts was investigated with intact chloroplasts isolated from sensitive grasses (Poaceae) and tolerant dicotyledonous plants (Pisum, Spinacia). The 4 herbicides (free-acid form)...
متن کاملMultifunctional acetyl-CoA carboxylase 1 is essential for very long chain fatty acid elongation and embryo development in Arabidopsis.
Acetyl-CoA carboxylase (ACCase) catalyses the carboxylation of acetyl-CoA, forming malonyl-CoA, which is used in the plastid for fatty acid synthesis and in the cytosol in various biosynthetic pathways including fatty acid elongation. In Arabidopsis thaliana, ACC1 and ACC2, two genes located in a tandem repeat within a 25-kbp genomic region near the centromere of chromosome 1, encode two multif...
متن کاملGroEL1: A Dedicated Chaperone Involved in Mycolic Acid Biosynthesis during Biofilm Formation in Mycobacteria
Mycobacteria are unusual in encoding two GroEL paralogs, GroEL1 and GroEL2. GroEL2 is essential--presumably providing the housekeeping chaperone functions--while groEL1 is nonessential, contains the attB site for phage Bxb1 integration, and encodes a putative chaperone with unusual structural features. Inactivation of the Mycobacterium smegmatis groEL1 gene by phage Bxb1 integration allows norm...
متن کاملThe role of phosphorylation/dephosphorylation of acetyl-CoA carboxylase in the regulation of mammalian fatty acid biosynthesis.
The main lipogenic tissues of the rat are the liver, white adipose tissue and, during lactation, the mammary gland. The rate of fatty acid synthesis de novo in these tissues must be regulated according to the nutritional and physiological status of the animal. Such short-term regulation is primarily achieved through the action of hormones. Acetyl-CoA carboxyulase is a prime target for such horm...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Microbiology
سال: 2009
ISSN: 1350-0872,1465-2080
DOI: 10.1099/mic.0.027714-0